1. Change in visual acuity.
2. Numerous neurological findings. A variety of neurological symptoms have been reported. Some patients have been diagnosed with Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and other well-known and recognized disorders, while others display significant symptoms not falling into any well-defined neurological category.
3. Gastrointestinal symptoms, which may include dyspepsia, gastroesophageal reflux, and/or changes in bowel habits often similar to Irritable Bowel Syndrome.
4. Neuropsychiatric symptoms and signs, ranging from mood or personality changes to diagnosed disorders including Attention Deficit Disorder, Bipolar Disorder, Obsessive Compulsive Disorder and occasionally frank psychosis. Temporal relationship to skin lesion onset is not known.
5. Acute changes in skin texture and pigment. The skin is variously thickened and thinned, with an irregular texture and irregular hyperpigmentation pattern. The changes resemble age associated sun-exposure skin damage, but typically appear acutely.
6. Skin examination often reveals excoriated and/or crusted lesions which, on examination with lighted magnification, are seen to have inclusions of variously colored (white, blue, black, or red) fibers. Skin examination may also reveal multiple hyper-pigmented macules, and an increase of what appears to be villous hair on arms and face.
7. Arthralgias are reported by many patients.
8. Associated diagnoses which have been commonly reported in this patient population include Borreliosis (better known as Lyme Disease), Fibromyalgia, and Chronic Fatigue Syndrome.